Prophet Lot (in English) was Abraham's nephew. Allah sent him to a transgressing people who used to commit abominable acts and indulge in their lusts with men rather than women. (Homosexuals).
Lot frequently preached to them to abandon such heinous crimes and come to the right course of Allah, but they never obeyed him. Being disappointed in them, Lot prayed Allah to destroy them, but save the believers among them. Because Lot's wife was apparently not a believer, her previous sympathy for the sinful people destined her to a miserable end along with her people.